Research Paper Volume 16, Issue 10 pp 8511—8523
LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4
Figure 1. SH3BP5-AS1 and miR-6838-5p have a relationship in HCC. (A, B) HCC cells and tissues showed increased SH3BP5-AS1 expression. (C) The patients’ advanced tumor stage was indicated by the elevated SH3BP5-AS1. (D) The position of SH3BP5-AS1 was identified using subcellular fractionation analysis. (E) The binding sites of SH3BP5-AS1 and miR-6838-5p. (F) MiR-6838-5p inhibited the activity of the luciferase gene in SH3BP5-AS1 wild-type (SH3BP5-AS1-WT), but not in SH3BP5-AS1 mutant (SH3BP5-AS1-MUT). (G) SH3BP5-AS1 prevented MiR-6838-5p from being expressed. (H) MiR-6838-5p mimics decreased SH3BP5-AS1 expression. (I) In HCC tissues, miR-6838-5p expression was markedly downregulated. (J) A negative correlation was observed between SH3BP5-AS1 and miR-6838-5p expression.