Research Paper Volume 16, Issue 10 pp 8484—8496
Shexiang tongxin dropping pill alleviates myocardial injury induced by coronary microembolization by down-regulating APOC1 to inhibit STAT3 signaling pathway
Figure 5. APOC1 binds STAT3 to regulate the activation of STAT3 signal pathway. Note: (A, B) western blot detected the expressions of APOC1, p-STAT3 and STAT3 after cell transfection with APOC1 overexpression or APOC1 knockdown, *P < 0.05, ** P < 0.01. (C) Immunofluorescence detected the expression of p-STAT3 in rat primary cardiomyocytes, scale bar of 25 μm; (D, E) Co-IP detected the binding of APOC1 with STAT3 and p-STAT3. Each experiment was repeated for 3 times.