Research Paper Volume 16, Issue 9 pp 7915—7927
IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis
Figure 3. IL21 inhibits chondrocyte proliferation by regulating the expression of miR-361-5p. (A)The expression of miR-361-5p in HC-a cells in the NC group and miR-361-5p mimics group was verified to verify the successful transfection of miR-361-5p mimics. (B) Proliferative capacity of HC-a cells after co-treatment with IL21 or IL21 and miR-361-5p.miR-361-5p can promote the proliferative ability of HC-a cells. (C) Cell cycle analysis of HC-1 cells after co-treatment with IL21 or IL21 and miR-361-5p. miR-361-5p can promote the S phase of HC-a cells stimulated by IL21. N = 8; **P < 0.01: miR-NC vs. miR-361-5p mimics; NC vs. IL21; IL21+miR-NC vs. IL21+miR-361-5p.