Research Paper Volume 16, Issue 9 pp 7704—7732
Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transition
Figure 6. Cell communication in various NK/T cell subtypes. (A, B) Representation of cell communication networks among different NK/T cell subtypes in primary (A) and liver metastasis (B) colorectal cancer tissues. (C) Application of bubble plots to depict the strength of cell communication outgoing and incoming signals. (D) Comparative assessment of signal strength from distinct secreted factors. (E, F) Heatmaps delineating the intensity of diverse outgoing (E) and incoming (F) signal patterns within NK/T cell subtypes. (G) Visualization of bubble plots highlighting the signal strength of ligand-receptor pairs involved in interactions between malignant cells and tumor stem cells with TEXs subtypes. (H) Exhibition of bubble plots displaying the signal strength of ligand-receptor pairs during the interactions of TEXs subtypes with malignant cells and tumor stem cells.