← Back
Research Paper Volume 16, Issue 8 pp 7217—7248

Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality

class="figure-viewer-img"

Figure 2. Homozygous deletion of METTL3 in murine hepatocytes by Alb-iCre mice (GPT) results in liver injury and acute liver failure (ALF). (A) Representative appearance of METTL3Δhep mice (GPT) at 21 days after birth. (B) Representative gross appearance of livers from control mice and METTL3Δhep mice (GPT) at 21 or 22 days postnatally. (C) Representative H&E staining photographs of liver sections from control mice and METTL3Δhep mice (GPT) at 21 days postnatally. Scale bar = 100 μm. (D) Representative appearance of control mice and METTL3Δhep mice (GPT) at 7 or 14 days after birth. (E–G) Body weight (E), liver weight (F) and liver-to-body weight ratio (G) of control mice and METTL3Δhep mice (GPT) at 7, 14 or 21 days after birth. (H, I) Serum levels of AST (H) and ALT (I) of control mice and METTL3Δhep mice (GPT).