Research Paper Volume 16, Issue 8 pp 7174—7187
Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1
Figure 2. Genetic alterations and DNA methylation levels of PDZK1 in glioma. (A) Summary of the alteration rates of PDZK1 in glioma (cBioPortal). (B, C) DNA methylation changes in PDZK1 in glioma assessed using the UALCAN database. * p < 0.05 compared with the control. (D) The methylation levels of the PDZK1 CpG island were analyzed by utilizing the EWAS Data Hub. (E) The relationship between the methylation levels of PDZK1 CpG islands and the expression of PDZK1 mRNA was analyzed by utilizing the EWAS Data Hub. (F) The OS of patients with gliomas stratified by the methylation level of the PDZK1 CpG island was analyzed via the EWAS Data Hub.