Research Paper Volume 16, Issue 7 pp 5829—5855
The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background
Figure 1. Potential effects of compounds on lifespan and health. A qualitative diagram of possible outcomes for compound effects on lifespan and on healthspan. Lifespan is represented as a change in median survival, while healthspan is represented in the relative rate of decline as compared to the control. The black lines show control, while the blue lines depict slowed aging, and the red lines depict accelerated aging. For health measures, the black dashed line shows the effects of an intervention that is generally stimulatory but does not alter the aging process. Depending on the effect size and direction, each healthspan, compound, and strain combination will fall into one quadrant: lifespan and healthspan extending, healthspan extending, gerospan extending, or toxic. The solid lines between the quadrants indicate no change from the control for a given measure.