Figure 3 — High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats

Research Paper|Volume 16, Issue 8|pp. 6937–6953

High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats

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Figure 3.High-dose VC suppressed the cardiomyocyte apoptosis in CLP-induced sepsis rats at 1d, 3d and 5d. (A) Apoptotic cells were detected by TUNEL staining. (B–F) Representative images of Caspase-3 activity, Cleaved-caspase 3, Cleaved-caspase 9, and Bax and Bcl-2 expression were examined by western blot and the fold activation data analysis. Data are expressed as mean ± SD (at least n = 6/group), ^#p < 0.05(vs. Sham group), ^*p < 0.05 (vs. CLP group).