Research Paper Volume 16, Issue 8 pp 6921—6936
Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation
Figure 7. CSD inhibited the expression of cGAS and the content of inflammatory factors in UC mice intestinal tissues. (A) Representative WB of cGAS in the intestine; (B) Statistical map of cGAS protein content in the intestine; (C) cGAS mRNA levels in the intestine; (D) IFN-β mRNA levels in the intestine; (E) ELISA measured the content of CCL17 in the intestine; (F) ELISA measured the content of IL10 in the intestine; (G) ELISA measured the content of TNF-α in the intestine; (H) ELISA measured the content of CXCL10 in the intestine; (I) CCL17 mRNA levels in intestine; (J) IL10 mRNA levels in intestine; (K) TNF- α mRNA levels in intestine; (L) CXCL10 mRNA levels in intestine. The results are mean ± SD, n = 3–6, *p < 0.05, ***p < 0.001 vs. DSS group.