Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation

Fei Gao; Shuangjiao Deng; Yujin Liu; Pengcheng Wu; Lifen Huang; Feng Zhu; Chunzhu Wei; Yuyi Yuan; Yang Gui; Yushi Tian; Heng Fan; Hui Wu

doi:doi:10.18632/aging.205734

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Research Paper Volume 16, Issue 8 pp 6921—6936

Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation

Figure 5. CSD alleviated symptoms and intestinal damage in UC mice. (A) Changes in body weight of mice; (B) Images of the colons of mice; (C) Statistical map of colon length in mice; (D) DAI score of mice; and (E) Mouse intestinal HE staining. (F) Mouse intestinal PAS staining. The results are mean ± SD, n = 6–8, ^**p < 0.01, ^***p < 0.001 vs. DSS group.