Research Paper Volume 16, Issue 7 pp 6510—6520
has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway
Figure 4. Promoting Effect of BDNF on ERK-related pathway protein expressions in glioma cells. (A) hsa-miR-134-5p is significantly downregulated and BDNF is significantly upregulated in detected by RT-PCR in glioma cells U251 and U87 cells, compared to Normal glioma cells. (B) Western blot shows expressions of related pathway proteins BDNF, p-TrKB, and ERK1/2 were significantly increased after oe-BNDF; expressions of related pathway proteins BDNF, p-TrKB, and ERK1/2 were significantly decreased after si-BNDF.