Research Paper Volume 16, Issue 7 pp 6488—6509
Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer
Figure 5. TCF19 on chromosome 6p21.33 can promote tumor cell proliferation, invasive and migratory ability by enhancing the transcription of SRSF6, etc., thus acting as a tumor-promoting factor in thyroid cancer, while Rs2073724 located in exon 3 of TCF19 negatively regulates the transcription and acts as a tumor suppressor. The C>T variant of rs2073724 affects the TCF19 function by damaging its transactivating ability.