Research Paper Volume 16, Issue 7 pp 6488—6509
Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer
Figure 3. Identification of TCF19[C] and TCF19[T] targets by RNA-seq. (A) Volcano plots displaying differentially expressed genes (DEGs) in microarray data comparing PCDH with TCF19[C] and TCF19[C] with TCF19[T] KTC-1 cells. The numbers of significantly variant genes (FC > 2.0, P < 0.05) were shown. Vertical dashed lines indicate cut-off of FC (2.0), whereas the horizontal dashed lines indicate cut-off of p-value (0.05). (B) Heatmap of DEGs identified by RNA-seq. (C) Gene Ontology (GO) enrichment analysis of DEGs, p-value<0.05. (D) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of DEGs, p-value<0.05. (E) Heatmap analyzed from 31 total genes obtained by the intersection of cluster 1 (PCDH vs TCF19[C]) and cluster 2 (TCF19[C] VS TCF19[T]). (F) GO analysis of genes described in (E). (G) KEGG analysis of genes described in (E).