Research Paper Volume 16, Issue 8 pp 6773—6795

Figure 7. HAPSTR1 exerts its oncogenic functions in ovarian cancer through LRPPRC. (A) Protein expression levels of LRPPRC were positively correlated with HAPSTR1 via Western blot. (B) Transfection efficiency of HAPSTR1 and LRPPRC were examined by Western blot. (C–E) The colony formation and transwell assays showed that the suppression of proliferative capacity induced by HAPSTR1 knockdown could be rescued by LRPPRC overexpression. Original magnification, 200x. (F–I) The CCK-8, colony formation, and transwell assays showed that the improvements in proliferative and metastatic capability caused by HAPSTR1 overexpression could be inhibited by LRPPRC knockdown. Original magnification, 200x. Each experiment was repeated with three independent replicates. *, p < 0.05; **, p < 0.01; ***, p < 0.001.