Figure 6. The effect of REEP4 on the immune microenvironment of LGG. (A) The expression level of receptor accessory protein 4 (REEP4) was positively correlated with the stromal, immune, and ESTIMATE scores. ***P < 0·001. (B) The correlation between REEP4 and 22 immune cell subtypes. *P < 0·05. **P < 0·01. ***P < 0·001. (C–K) REEP4 expression is positively correlated with 8 immune checkpoints, including CD274, PDCD1, KLRB1, LAG3, CD96, CD276, CTLA4, HAVCR2, CD163.