Research Paper Volume 16, Issue 7 pp 6188—6211
Potential value of expression of receptor accessory protein 4 for evaluating the prognosis of lower-grade glioma patients
Figure 4. Methylation level of receptor accessory protein 4 (REEP4) in lower-grade glioma (LGG) based on the TCGA database. (A) Methylation sites of REEP4 in LGG. (B) The expression level of REEP4 is negatively correlated with the total methylation level. (C–H) The expression level of REEP4 is negatively correlated with methylation sites cg13265914, cg16311504, cg07664173, cg20582089, cg19738333 and cg02498268. (I) The expression level of REEP4 is positively correlated with the methylation site cg02399048. (J) Effect of methylation site cg16311504 on the overall survival of patients with LGG. (K) Real-time quantitative polymerase chain reaction showing that the expression level of REEP4 was significantly inhibited by SAM. ****P < 0·0001.