Research Paper Volume 16, Issue 7 pp 6135—6146
Lifibrate attenuates blood-brain barrier damage following ischemic stroke via the MLCK/p-MLC/ZO-1 axis
Figure 6. Lifibrate reserved expression of the tight junction protein ZO-1 against OGD/R in bEnd.6 cells. Cells were exposed to hypoxic conditions for 6 h, followed by exposure to reperfusion media for 24 h in the presence or absence of Lifibrate (3, 6 μM). (A) mRNA of ZO-1; (B) Protein expression of ZO-1 (n=6, **, P<0.01 vs. vehicle group; #, ##, P<0.05, 0.01 vs. OGD/R group).