Research Paper Volume 16, Issue 7 pp 6118—6134
A novel risk signature based on liquid-liquid phase separation-related genes reveals prognostic and tumour microenvironmental features in clear cell renal cell carcinoma
Figure 8. Expression validation of key genes in risk signatures of LLPS-related genes and single-cell analysis. (A) Unpaired expression analysis of the five key genes in the TCGA-KIRC cohort; (B) Paired expression analysis of the five key genes in the TCGA-KIRC cohort; (C) Expression of the five key genes in renal carcinoma cell lines (OSRC-2, Caki-1, and 786-O), with renal normal epithelial cells (HK-2) as a reference; (D) Key gene expression in ccRCC tissues and corresponding normal kidney tissues collected from our research centre; (E, F) GSE159115 cohort analysed the expression of five genes in immune cells, malignant cells and stromal cells; (G, H) GSE139555 analysed the expression of five genes in different cellular abundance; (I, J) GSE121636 further analysed the expression of five genes in different cells. (*p < 0.05, **p < 0.01, ***p < 0.001, “ns”: not statistically significant).