Identification of key pathways and mRNAs in interstitial cystitis/bladder pain syndrome treatment with quercetin through bioinformatics analysis of mRNA-sequence data

Guang Wang; Pei Li; Si-Wei Su; Rui Xu; Zi-Ye Huang; Tong-Xin Yang; Jiong-Ming Li

doi:doi:10.18632/aging.205682

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Research Paper Volume 16, Issue 7 pp 5949—5966

Identification of key pathways and mRNAs in interstitial cystitis/bladder pain syndrome treatment with quercetin through bioinformatics analysis of mRNA-sequence data

Figure 2. The effect of QCT on IC/BPS rats. ELISA kit detected the concentration of IL-1β (A), IL-6 (B), MPO (C), TNF-α (D). (E) HE staining was used to deserve the inflammatory of bladder tissue in rat. (F, G) Changes of collagen fibers in rat bladder tissue was performed by Masson staining. (H, I) TB staining observed the mast cells in bladder tissue of rat. (J) The degranulation of mast cells in rat bladder tissue was observed by transmission electron microscope. One-way ANOVA was used. Compared with Ctrl group, ^**P < 0.01, ^***P < 0.001. Compared with IC/BPS group, ^ΔP < 0.05, ^ΔΔP < 0.01, ^ΔΔΔP < 0.001. n = 3.