Research Paper Volume 16, Issue 7 pp 5916—5928

Figure 1. 5-FU causes cardiomyocyte damage and impaired cardiac function of SD rats. Two doses, 200 and 400 μM were used for in vitro analysis and 25 and 50 mg/kg were adopted for in vivo analysis. (A) 5-FU decreases the viability of cardiomyocytes in both doses; (B–D) 5-FU causes decreasing of SOD activity and GSH/GSSG ratio, and increases LDH levels in primary cardiomyocytes; (E) 5-FU did not cause obvious impaired left ventricular cardiac function in rats, although it led to a downward trend; (F) HE staining indicates that 5-FU caused myocardial injury, which demonstrated as intermuscular inflammatory cell infiltration and focal necrosis in myocardial tissue.