Research Paper Volume 16, Issue 6 pp 5581—5600
Correlation between S100A7 and immune characteristics, methylation, tumor stemness and tumor heterogeneity in pan-cancer and its role in chemotherapy resistance in breast cancer
Figure 12. S100A7 reduced the chemosensitivity of breast cancer cells in vitro. (A) The CCK-8 assay showed that knockdown of S100A7 reduced the IC50 of MCF7 and MDA-MB-231 cells towards Taxol. The wound healing assay showed that knockdown of S100A7 inhibited the migration of (B) MCF7 and (C) MDA-MB-231 cells after Taxol treatment (MCF7: 0.05 mg/L, MDA-MB-231: 1 mg/L). *P < 0.05; **P < 0.01; ***P < 0.001. All experiments were repeated thrice. IC50, half-maximal inhibitory concentration.