Research Paper Volume 16, Issue 6 pp 5435—5451
Identification of key lncRNAs in age-related macular degeneration through integrated bioinformatics and experimental validation
Figure 8. Cell senescence analysis. (A) Control group. (B) t-BH (30 μM) group. (C) Proportion of senescent cells in groups A and B. *** means P<0.001 compared with control group. After the senescence model was established, the cell body was enlarged and stained blue by the reagent (scale bar indicated as 100 μm). The percentage of senescent cells was significantly increased in group treated with t-BH compared with normal group through SA-β-gal staining compared with control group. (D) By using RT-PCR, the mRNA levels of and IFIT3 were detected. The expression of LINC00276 and IFIT3 was dramatically downregulated in the senescent cell as compared to the control group, * means P<0.05 compared with control group.