Research Paper Volume 16, Issue 5 pp 4889—4903
5-Hydroxytryptophan acts as a gap junction inhibitor to limit the spread of chemotherapy-induced cardiomyocyte injury and mitochondrial dysfunction
Figure 2. 5-HTP ameliorates DOX-induced cardiac dysfunction of myocardial tissue in mice. (A) Bodyweight of mice on the last day of the experiment; (B) Morphology of the mice heart; (C) Representative echocardiographic images; (D) Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS); (E) Left ventricular internal diastolic end-systolic (LVIDs) and left ventricular internal diastolic end-diastolic (LVIDd); (F) Heart rate (HR); *P < 0.05 vs. the Control group, #P < 0.05 vs. the DOX group. (L-5-HTP group: L-5-HTP+DOX; M-5-HTP group: M-5-HTP+DOX; H-5-HTP group: H-5-HTP+DOX).