Research Paper Volume 16, Issue 5 pp 4862—4888

Figure 3. KIRC patients were grouped in 3 clusters based on LDCD-RGs expression levels. (A) Based on TCGA data, a heatmap generated through cluster analysis illustrates three subgroups of KIRC: Highly Active LDCD (C1), Normal LDCD (C2), and Suppressed LDCD (C3), categorized according to the mRNA expression levels of 50 LDCD-RGs. (B) Violin plots created using the “ggpubr” package depict the enrichment scores of the three subgroups in descending order: C1, C2, and C3. (C) Comparison of survival curves among the three KIRC subgroups reveals differing survival times (C1 > C2 > C3). The pink line represents C1; the green line represents C2; and the black line represents C3. The horizontal axis denotes time (years), while the vertical axis represents survival rate. Abbreviations: LDCD-RGs: LDCD-related genes; LDCD: Lysosomal-dependent cell death; KIRC: kidney renal clear cell carcinoma.