Research Paper Volume 16, Issue 5 pp 4789—4810
SORBS1 inhibits epithelial to mesenchymal transition (EMT) of breast cancer cells by regulating PI3K/AKT signaling and macrophage phenotypic polarization
Figure 8. SORBS1 induces THP-1 polarization to inhibit breast cancer cell proliferation and invasion. (A) Schematic diagram of THP-1 cells co-cultured with SORBS1. (B) Changes in the co-culture viability of MDA-MB-231 and SKBR3 cells after 48 h of co-culturing as detected by CCK8 assay. MB-231 and SKBR3 cell viability changes. (C) Changes in MDA-MB-231 and SKBR3 cell invasive ability after 48 h of co-culture as detected by transwell assay and by CCK8 assay (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001).