Research Paper Volume 16, Issue 5 pp 4670—4683

Figure 6. Echinatin enhances learning and memory capabilities of mice exposed to sevoflurane. (A) Changes in mice body weight after injection of different concentrations of Echinatin. For in vivo experiments, mice exposed to sevoflurane (3%) were intraperitoneally administered Echinatin at a dose of 20 mg/kg. (B) Protein levels of FPN, TFR1, and DMT1 in hippocampal tissue were assessed using western blot analysis. (C–E) Expression levels of TNF-α, IL-1β, IL-6, GSH, and SOD in hippocampal tissue were measured by commercial kits. (F) Escape latency during Morris water maze testing. (G) Swimming distance during Morris water maze testing. (H) Time in target quadrant during Morris water maze testing. (I) Swimming velocity during Morris water maze testing. The data are presented as the mean ± SD. Ech, Echinatin; Sevo, sevoflurane. Compared with the Sevo group, **P<0.01, ***P<0.001.