Figure 1. Construction of osteoarthritis mice model. (A) Cartilage HE staining results of OA model and controls. (B) Apoptosis of chondrocytes was detected by TUNEL immunofluorescence. (C) ELISA was used to detect the expression of IL-1β, IL-18, and TNF-α in the serum of mice models and controls. (**P < 0.01 vs. sham, n = 6).