Figure 15 — Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8

Research Paper|Volume 16, Issue 5|pp. 4469–4502

Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8

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Figure 15.The role of MXRA8 in PC-3 cells. (A, B) PCR and immunohistochemistry results suggest that MXRA8 is highly expressed in prostate cancer tissues; (C) After knocking out MXRA8, the cell viability of PC-3 cells decreased; (D) After knocking out MXRA8, the ROS production ability of PC-3 cells increased; (E) After knocking out MXRA8, the proliferation ability of PC-3 cells decreased; (F, G) After knocking out MXRA8, the migration and invasion ability of PC-3 cells decreased; (H) The expression of MXRA8 in pancreatic cancer tissues was higher than that in normal tissues.