Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene <i>MXRA8</i>

Miao Miao; Yan Song; Mingyue Jin; Yang Du; Peng Xin; Yuanjun Jiang; Hao Zhang

doi:doi:10.18632/aging.205599

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Research Paper Volume 16, Issue 5 pp 4469—4502

Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8

Figure 15. The role of MXRA8 in PC-3 cells. (A, B) PCR and immunohistochemistry results suggest that MXRA8 is highly expressed in prostate cancer tissues; (C) After knocking out MXRA8, the cell viability of PC-3 cells decreased; (D) After knocking out MXRA8, the ROS production ability of PC-3 cells increased; (E) After knocking out MXRA8, the proliferation ability of PC-3 cells decreased; (F, G) After knocking out MXRA8, the migration and invasion ability of PC-3 cells decreased; (H) The expression of MXRA8 in pancreatic cancer tissues was higher than that in normal tissues.