Research Paper Volume 16, Issue 5 pp 4378—4395
The prognosis, chemotherapy and immunotherapy efficacy of the SUMOylation pathway signature and the role of UBA2 in lung adenocarcinoma
Figure 1. Landscape of genetic variation and correlation of SUMOylation pathway-related genes in LUAD. (A) The heat map demonstrates the differential expression of SUMOylation pathway genes between LUAD and adjacent non-tumor tissues. (B) Univariate survival analysis results of SUMOylation pathway genes in LUAD patients. (C) The chromosomal locations of the 12 SUMOylation pathway genes were determined. (D) Pathway analysis of SUMOylation pathway genes in LUAD. (E) The number of patients with mutations in SUMOylation pathway genes using TCGA-LUAD cohort. (F) Oncoplots showing the mutation landscape of SUMOylation pathway genes in LUAD patients from TCGA-LUAD cohort. *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001.