Figure 4 — Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway

Research Paper|Volume 16, Issue 5|pp. 4363–4377

Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway

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Figure 4.Probucol reduces CCH-induced microglial activation and pyroptosis. (A, B) Immunofluorescence of Iba1/DAPI. Representative photomicrographs of microglial activation in the Hippocampal region (scale bar = 50 μm). (C) Pyramidal cell layer HE staining results (scale bar = 40 μm). (D) WB assay of pyroptotic markers (NLRP3, ASC, and Caspase-1) and inflammatory cytokines (IL-1β and IL-18). Data are expressed as mean ± SEM. n = 12/group. ^**P < 0.01: CCH group vs. Probucol group.