Research Paper Volume 16, Issue 5 pp 4363—4377
Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway
Figure 4. Probucol reduces CCH-induced microglial activation and pyroptosis. (A, B) Immunofluorescence of Iba1/DAPI. Representative photomicrographs of microglial activation in the Hippocampal region (scale bar = 50 μm). (C) Pyramidal cell layer HE staining results (scale bar = 40 μm). (D) WB assay of pyroptotic markers (NLRP3, ASC, and Caspase-1) and inflammatory cytokines (IL-1β and IL-18). Data are expressed as mean ± SEM. n = 12/group. **P < 0.01: CCH group vs. Probucol group.