Research Paper Volume 16, Issue 5 pp 4363—4377
Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway
Figure 1. Probucol improves CCH-induced spatial learning and memory. (A) Path map of the Morris water maze in sham group, CCH group, and probucol group. (B) Escape latencies of rats in the hidden platform task; Frequency of crossing the platform in the space exploration test; Percentage of residence time in the target quadrant during the space exploration test; Average swimming speed of rats in the visible platform test. (C) Statistics on the number of center crossings in the control group, sham operation group, CCH group and probucol group; Statistics of time in the center of the control group, sham group, CCH group and probucol group; Travel distance statistics of control group, sham operation group, CCH group and probucol group; Standing time statistics of rats in the control group, sham operation group, CCH group and probucol group. Data are expressed as mean ± standard error of mean (SEM). n = 12/group. **P < 0.01: CCH group vs. Probucol group.