Research Paper Volume 16, Issue 13 pp 10765—10783

Figure 6. Possible signaling pathways that contribute to renal carcinoma progression. (A) IPA analysis identified the interaction between CALCR and NF-κB signaling, integrin signaling, PI3K/AKT signaling, ERK/MAPK signaling, Wnt/β-catenin signaling and NGF signaling. (B) Human phospho-kinase array analysis suggested the significant changes in phosphorylation levels of c-jun and STAT1 after silencing CALCR. Results were presented as mean ± SD. ^*p < 0.05, ^**p < 0.01. Abbreviations: IPA: ingenuity pathway analysis; NF-κB: nuclear factor-kappa B; PI3K: phosphoinositide 3-kinase; AKT: protein kinase B; ERK: extracellular signal-regulated kinase; MAPK: mitogen-activated protein kinase; Wnt: wingless-related integration site; NGF: nerve growth factor; STAT1: signal transducer and activator of transcription 1.