Research Paper Volume 16, Issue 5 pp 4250—4269

Figure 7. LSF attenuates the deterioration of OA in DMM mice. (A) Representative images of Micro-CT 3D reconstruction of mice knee joints. Mice were randomly assigned to treatment groups with different concentrations of LSF (0.08, 0.17, and 0.35 g/kg) after DMM surgery and received LSF via intragastric administration for 4 weeks. All mice were executed at 8 weeks postoperatively, Scale bar: 1 mm. (B) Typical images of mouse knee joints stained with HE, ABH/OG and Safranin O Fast green staining after pathologic sectioning. Scale bar: 50 μm. (C–F) Quantitative data of BV/TV, Tb.Th, Tb.N, and Tb.Sp of the subchondral bone in each group of mice at 8 weeks postoperatively. (G) OARSI score of the cartilage. All data represent mean ± SD. Compared to the SHAM group; **p ≤ 0.01, ***P < 0.001, ****P < 0.0001; compared to the DMM group, *P<0.05, **P < 0.01, ***P < 0.001.