Research Paper Volume 16, Issue 4 pp 3989—4013
Unlocking the potential of senescence-related gene signature as a diagnostic and prognostic biomarker in sepsis: insights from meta-analyses, single-cell RNA sequencing, and in vitro experiments
Figure 2. Differential expression of senescence-related genes in sepsis vs control samples. (A) Heatmap showing the level of expression of 80 senescence-related genes showing expression difference in sepsis and control samples. (B) Volcano plot displaying the fold change (log2) and statistical significance (-log10 adjusted p-value) for each gene. The red dots indicate up-regulated genes, while the blue dots indicate down-regulated genes. (C) A PPI network of the 80 differentially expressed genes associated with senescence. (D) Functional annotation of the 80 differentially expressed genes. Abbreviations: PPI, protein-protein interaction.