Research Paper Volume 16, Issue 5 pp 4191—4203
Calycosin (CA) inhibits proliferation, migration and invasion by suppression of CXCL10 signaling pathway in glioma
Figure 3. CXCL10 overexpression reduces the effects of calycosin on cells proliferation, migration, invasion and CXCL10 signaling in GBM. (A–D) Effect of CXCL10 overexpression on calycosin in U87 and U251 cell proliferation. (E–H) Effect of CXCL10 overexpression on calycosin in U87 and U251 cell migration and invasion. (I) Overexpressing CXCL10 rescues calycosin-induced CXCL10, NLRP3, NF-κB and IL-1β downregulation. Control: GFP lentivirus transfection; CA: GFP lentivirus transfection + 200μM calycosin; oe-CXCL10: lentivirus transfection CXCL10; Both: lentivirus transfection CXCL10 + 200μM calycosin. *P < 0.05 vs control. #P < 0.05, compared with either CA treatment or CXCL10 transfection alone.