Research Paper Volume 16, Issue 4 pp 3856—3879

Figure 2. Identification of dysregulated co-expression modules. (A) Flowchart of the research design. (B) Volcano plot of differentially expressed genes between normal and UC patients. The volcano plot displays the log2 fold change on the x-axis and -log10(p-value) on the y-axis. (C) The significant associations among gene significances, module memberships, and the disease severity in the turquoise module. (D) Correlation between module eigengenes and the occurrence of UC. (E) Global differences in differential gene expression between UC patients and normal people in the GSE87466 cohort. The Euclidean expression distances were calculated between UC and normal (red), within samples of UC (lilac), and within samples of normal (grey). The inset summarizes the average distances between pairs of tissues as a percentage of the average distance between UC and normal people.