Research Paper Volume 16, Issue 4 pp 3837—3855

Figure 1. DKK1 expression in different cancers and its relationship with individual clinical characteristics of HNSCC. (A) DKK1 mRNA expression levels in different types of cancer tissues compared to that in normal tissues, based on information in the Oncomine database. (B) DKK1-expression levels in different cancers in the TIMER database. (C, D) DKK1-expression levels in representative HNSCC samples and normal tissues, as determined using IHC. The DKK1 levels were higher in HNSCC tissues than in normal tissues (P = 0.0024). (E) Differences in DKK1 expression in various HNSCC sample types, based on information deposited in the UALCAN database. (F) DKK1 exhibited a high diagnostic value for distinguishing between tumor and normal tissues. (G–J) DKK1 mRNA expression levels were remarkably correlated with the tumor grade (H), nodal-metastasis status (I), and HPV status (G, J) of patients with HNSCC, based on information from the UALCAN database (***p < 0.001, **p < 0.01, *p < 0.05).