Research Paper Volume 16, Issue 4 pp 3790—3802
MUC1 promotes RIF by regulating macrophage ROS-SHP2 signaling pathway to up-regulate inflammatory response and inhibit angiogenesis
Figure 2. Diagnostic efficiency of hub genes and validation. (A) ROC analysis of each hub gene using dataset 111974. Only the hub genes whose AUC was higher than 0.75 were selected. The expression levels of selected hub in dataset 111974 (B), dataset 92324 (B), and local plasma samples (C, D). (E) ROC analysis of each hub gene using local plasma samples. (F) ROC analysis of gene set using local plasma samples, dataset111974 and dateset92324. Gene set means a 4-gene (MUC1-PTGS1-PTGS2-CXCL11) signature. *p < 0.05, ***p < 0.001. Abbreviations: ROC: receiver operating characteristic; AUC: area under the curve.