Research Paper Volume 16, Issue 4 pp 3694—3715

Figure 3. PPI network of SDEGs and subnetwork. (A) PPI network construction of differential genes in GeneMANIA database. Red dots: significant up-regulate differential genes; Blue dots: significant down-regulate differential genes; Black dots: related genes added by the GeneMANIA database for the associate PPI network. Circle size indicated the degree of the corresponding gene in the PPI network. The larger the circle is, the greater degree of the corresponding node in the figure, which can explain why this node is more important in the network from the point of view of graph theory. (B, C) Utilising the MCODE plug-in to analyse the PPI network, two key subnetworks were obtained (Figure 3B: the subnetwork of Score8.5; Figure 3C: the subnetwork of Score6.182.).