Research Paper Volume 16, Issue 4 pp 3554—3582

Figure 7. The expression of SLC30A7 and its effect on proliferation, invasion, migration and epithelial mesenchymal transformation of primary GBM cells. (A–C) Boxplots showing the SLC30A7 distributions according to grade, molecular subtype, and histology in CGGA cohort (P < 0.001). (D) Expression of SLC30A7 in normal tissues and GBM. (E) Proliferation of cells stably transfected with SLC30A7 knockdown lentivirus in different group. Significant results are indicated as ^**p < 0.01. (F–I) Cell scratch and Trans-well assays detected the invasion and migration of GBM primary cells after inhibition of SLC30A7, H is the statistic of the migration distance in scratch assay at different time points, I is the counting of the invasion penetrated out chamber cells after Transwell assay. Significant results are indicated as ^**p < 0.01, and ^***p < 0.001.