Research Paper Volume 16, Issue 4 pp 3554—3582

Figure 1. Landscape of genetic and expression variation of cuproptosis regulators in GBM. (A) Essential regulators in cuproptosis events, and their biological functions. (B) Principal component analysis of total 13 cuproptosis regulators for distinguishing tumour from normal patients in merge cohort (TCGA and GTEx). (C) The CNV mutation frequency of 13 cuproptosis regulators in TCGA cohort. The column represented the alteration frequency. The deletion frequency, green dot; The amplification frequency, red dot. (D) Differential expression of cuproptosis regulators between normal and GBM tissues. GBM, blue; LGG, yellow; Normal, red. Significant results are indicated as ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001. (E) The mutation frequency of key cuproptosis regulators in TCGA-GBM cohort. Each column represented individual patients. The upper barplot showed TMB. (F) The location of CNV alteration of cuproptosis regulators on chromosomes in TCGA-GBM cohort.