Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human

Junxian He; Jindong Li; Yanqing Li; Zhenhan Xu; Menghui Ma; Haicheng Chen; Peigen Chen; Linyan Lv; Xuejun Shang; Guihua Liu

doi:doi:10.18632/aging.205538

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Research Paper Volume 16, Issue 4 pp 3350—3362

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human

Figure 2. Leydig cells highly expressed differentially expressed SASP-related gene in aging testis. (A) Cell-cell communication between You and Old samples. (B) Volcano plot showing DEGs between You and Old samples, (Wilcoxon, adjusted p-values < 0.05, LogFC > 0.5) (SASP-related genes, yellow). (C) Dot plot showing IGFBP7 expression enriched in older samples.