Research Paper Volume 16, Issue 4 pp 3200—3230
Transcriptomic and network analysis identifies shared and unique pathways and immune changes across fibrotic interstitial lung diseases
Figure 4. Network and pathway analyses of DEGs in the lung tissues of IPF patients. Network and pathways were performed on the dataset from IPF patients compared to healthy controls to identify unique dysregulated pathways in the lung tissues of IPF. (A, B) Network analysis of up-regulated genes and down-regulated genes. Most significant hub genes, according to degree and betweenness centrality, with the highest number of connections, are enclosed in ovals. (C, D) Function enrichment analysis of the up-regulated and down-regulated common DEGs, where the horizontal axis represents the proportion of DEGs under the functional terms. Top 5 pathways with most significant P-value were shown and ordered by gene ratio.