Research Paper Volume 16, Issue 3 pp 2828—2847

Figure 6. MiR-124 attenuates the brain infarct volume, brain oedema, and neuronal damage, while improving the neurological reflex behavior of rats with HIBD in vivo. (A) Overview of animal experiments procedures in the HIBD rat model; (B) Representative TTC stained coronal brain sections of each group (number of animals: n=5/group); (C) Representative images of newborn SD rat brain taken by digital camera after HI injury (number of animals: n=5/group); (D) Nissl staining and H&E staining of cerebral cortex region in each group(number of animals: n=5/group). Scale bar, 50μm; (E) Quantitative analysis of ipsilateral cerebral infarction volume in each group; (F) Quantitative analysis of brain water content; (G) Neurological score (number of animals: n=10/group); (H) Righting reflex times (number of animals: n=10/group); (I) Negative geotaxis reflex times (number of animals: n=10/group); Data are expressed as the mean ± SD. P < 0.05. NS, not significant for p > 0.05, * p < 0.05, ** p < 0.01, and *** p < 0.001 (one-way analysis of variance with Tukey’s post hoc tests).