Research Paper Volume 16, Issue 3 pp 2753—2773
Integrative analysis of single-cell and bulk RNA-sequencing data revealed disulfidptosis genes-based molecular subtypes and a prognostic signature in lung adenocarcinoma
Figure 4. Development and assessment of a DRG-based prognostic model in the TCGA population. (A) Cross-validation for selecting the tuning parameter (λ) in the LASSO model. (B) The coefficient profile of prognostic DRGs using the LASSO method. (C) The multivariate Cox regression analysis of DRGs was presented through a forest plot. (D, E) The heatmap illustrates the differential gene expressions within the DRG prognostic model between the high- and low-risk cohorts in both the TCGA training and testing cohorts. (F, G) Risk score distribution plot and risk point plot between the high- and low-risk groups in TCGA training and testing cohorts. (H, I) The Kaplan-Meier OS curves for patients in two risk groups in TCGA training and testing cohorts. (J, K) ROC curves showed the prognostic performance of the DRG prognostic model in TCGA training and testing cohorts.