Research Paper Volume 16, Issue 3 pp 2715—2735
Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma
Figure 4. The immune characteristic of BMS groups. (A) Distribution of immune infiltrating cells between BMS groups using seven mainstream algorithms. (B) Correlation analysis of immune infiltrating cells between BMS groups using seven mainstream algorithms. (C) Abundances of main immunosuppressive infiltrating cells (MDSCs, macrophages, and regulatory T cells) in TME in two subgroups. (D) Samples in the high-BMS group exhibited higher ESTIMATE, stromal, and immune scores than the low-BMS group. (E) Association between BMS and the previously reported pan-cancer immune subtypes. (F) Differences in the 13 immune-related functions between high- and low-BMS groups. (G) Evaluation of the anticancer immunological functions of the seven-step cancer-immunity-cycle between high- and low- BMS groups. Wilcox test was used, and the asterisks represent the statistical P-value (*p <0.05, ** p <0.01, *** p <0.001).