Research Paper Volume 16, Issue 2 pp 1663—1684
Usenamine A triggers NLRP3/caspase-1/GSDMD-mediated pyroptosis in lung adenocarcinoma by targeting the DDX3X/SQSTM1 axis
Figure 7. Usenamine A inhibits LUAD tumor growth by regulating DDX3X. promotes NLRP3/caspase-1/GSDMD-mediated pyroptosis by upregulating the DDX3X/SQSTM1 axis in vivo. (A) Tumor weight and volume. **p < 0.01 vs. control; $$p < 0.01 vs. usenamine A + sh-DDX3X. (B) Protein expression of Ki67, N-cadherin, and E-cadherin in tumor tissues was measured by immunohistochemical staining. Scale bar = 20 μm. (C) Apoptosis in tissues was detected by TUNEL staining. Scale bar = 20 μm. LUAD, lung adenocarcinoma; DDX3X, DEAD-Box helicase 3 X-Linked.