Research Paper Volume 16, Issue 2 pp 1536—1554

Figure 7. Analysis of the correlation between sarcoma risk score and tumor immune infiltration. (A) The degree of immune infiltration and immune function status of high- and low-risk groups were calculated using ssGSEA. In the low-risk group, there was a higher degree of immune infiltration of aDCs, B cells, cytotoxic cells, DCs, eosinophils, iDCs, mast cells, NK cells, pDCs, T cells, Tcm, and Tgds than in the high-risk group, while Th2 cells were more infiltrated in the high-risk group than those in the low-risk group (P < 0.05). (B) In comparison with the high-risk group, the low-risk group had higher scores for APC co-inhibition immune function scores, HLA, inflammation-promoting, check-point, cytolytic activity, T cell co-inhibition, T cell co-stimulation, type I IFN response and type L IFN response (P < 0.05). (C) An ESTIMATE algorithm was used in calculating stromal scores, immune scores, and estimation scores. Abbreviation: ESTIMATE: estimation of stromal and immune cells in malignant tumor tissues using expression data. Statistical significance is indicated by an asterisk: ^*p < 0.05; ^**p < 0.01 and ^***p < 0.001.