Research Paper Volume 16, Issue 2 pp 1496—1515
The miR-146b-3p/TNFAIP2 axis regulates cell differentiation in acute myeloid leukaemia
Figure 1. Differentially expressed genes and TNFAIP2-correlated genes in AML patients. (A) The transcript level of TNFAIP2 was significantly decreased in AML samples compared with normal samples in the Oncomine database. (B) The expression of TNFAIP2 mRNA was markedly decreased in AML samples compared with normal samples in the GSE9476 dataset. (C) Volcano plot of TNFAIP2-correlated genes. (D) Heatmap of the top 50 genes positively correlated with TNFAIP2, based on correlation coefficients. (E) Heatmap of the top 50 genes negatively correlated with TNFAIP2, based on correlation coefficients. BM: normal bone marrow samples. Normal distribution, t test, ** P < 0.01.