Research Paper Volume 16, Issue 2 pp 1336—1351

Cisplatin and doxorubicin chemotherapy alters gut microbiota in a murine osteosarcoma model

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Figure 7. PICRUSt2 functional predictive analysis. (A) KEGG difference clustering heatmap. Kruskal–Wallis analysis was performed to predict pathways. The clustering of different enrichment entries is exhibited in the left cluster tree, and the upper clustering branch represents different samples. (B) COG difference clustering heatmap. (C) COG bar plot. The sample names are on the X-axis, and the relative abundance of the predicted functions is on the Y-axis. Abbreviations: PICRUSt2: phylogenetic investigation of communities by reconstruction of unobserved states; KEGG: Kyoto Encyclopedia of Genes and Genomes; COG: Clusters of Orthologous Groups of proteins.